Vidalista 20mg is safe when used as directed. This medication should only be used by physicians with extensive knowledge of PAH. If you have any concerns, consult your doctor immediately. The drug significantly improved the rate of patients achieving a sustained erection in both groups. However, the placebo group failed to maintain a sustained level of successful penetration, intercourse, and satisfaction. Tadalafil-depoxetine combination is dangerous when combined with protease inhibitors. It can increase tadalafil plasma concentrations in the body. In some cases, it can cause a fatal heart attack.